At present, planning theory and practice has always regarded technological innovation and industrial revolution as exogenous variables, and seldom discussed the systematic impact of technological progress on space. At present, scientific and technological innovation is very rapid, and new concepts such as “the third industrial revolution”, “industry 4.0” and “the fourth industrial revolution” have emerged. With the deepening of relevant discussions, it is necessary try to deeply grasp the spatial impact of technological innovation and industrial revolution through in-depth analysis. In theory, technological progress continues to shape the spatial form of cities and villages. The fourth revolution will change the “rules” of economic growth and industrial development, as well as the rules of spatial evolution. It will not only transform the strategic industries and leading industries, but also reconstruct the mode of production organization. Technological innovation and industrial revolution is a complex process, which is a magnificent and colorful picture. Specifically speaking, it is a process of general-purpose technology renewal, basic energy iteration, and leading industry transformation. It is a historical process in which multiple innovation waves interweave and play a role, rather than a leap overnight. Technological revolution brings irreversible structural changes such as new industries, new organizational models and new industrial spatial forms, and also embeds reversible cyclical cycle, which affects the fate of the country, the city and the society. Therefore, the technological revolution will also change the fate of cities and villages, and generally speaking, will show an unbalanced duality. Why do we say that there is spatialtemporal imbalance in technology diffusion? This is because technological progress will encounter the “exclusion” reaction of institution and culture, in other words, the isolation of “the Braudel Bell Jar”. Technological innovation has also shaped emerging leading industries, transformed the demand for corresponding resource, resulting in great disparity between different cities, and brought differences in production mode, production organization mode and industrial space form. At the same time, these development realities guide the direction of urban industrial space transformation and upgrading. Therefore, it is necessary to analyze the law of industrial revolution. On this basis, according to the reality of local industry and spatial development, the paper puts forward that industrial space should be oriented to innovation driven, transformation and upgrading. In the industrial development and spatial evolution of Chongqing, we can clearly identify the traces left by the technological revolution, and also need to think about the transformation and upgrading of Chongqing’s industrial space in the new context. Since 1978, Chongqing has changed from a traditional heavy industrial city to a dynamic mixed economy, from a decentralized manufacturing base to a diversified and complex modern industrial space. Chongqing has made great achievements in economic development. However, due to land shortage, path dependence, peer competition and other reasons, there are still problems such as high proportion of heavy industry in industry, long industrial space distance, weak ability of independent innovation and so on. In the context of new industrial revolution, it is necessary to rethink the cultivation of new industries and industrial space optimization, as well as the innovation ecology guidance and formation. In the context of the new industrial revolution, Chongqing’s industrial space needs to be upgraded to innovation driven. In order to achieve this goal, it should select appropriate emerging industries, fully stimulate the correlation effect between industries, properly guide the spatial choice of enterprises, optimize the industrial spatial development platform, and guide the formation of innovation ecology and culture. In the process of transformation and upgrading, Chongqing should not disobey its comparative advantage, and should choose appropriate strategic emerging industries to carry out secondary innovation, and pay attention to the industrial correlation effect. At the same time, Chongqing needs to strengthen the integration of industrial space, provide sufficient space for the cultivation of emerging industries, and effectively enhance the agglomeration economy. Chongqing also needs to guide the formation of innovation ecology and culture, and improve the number of independent innovation. Of course, industrial space upgrading is a system engineering, which is a complex action that is difficult to predict and control under the influence of many factors. Therefore, Chongqing not only needs to continue to work hard in gathering high-end elements, but also needs to continue to vigorously promote external connections, and more actively integrate into the global innovation chain and industrial chain. Thus, we can continuously tap our own unique advantages, make up for the defects in the past development, optimize our own choice under the constraints of geographical location and traffic conditions, and obtain the best development effect.