Urban construction, government management and community management were assaulted by the outbreak of new coronavirus pneumonia (NCP) in early 2020. This epidemic triggered a deep reflection and extensive discussion in urban research. As the minimum unit of the national space governance system, the community has become the focus and also be a basic foothold for many experts and scholars to study the epidemic suppression and prevention. Therefore, the level of community prevention and anti-epidemic capacity has become important issues. Nanning, as the capital city of Guangxi Autonomous Region, because of its higher urban prestige, developed external transportation system, and the most densely populated flow, it has become the easiest infected areas and the highest number of infection by the epidemic in the entire region. Based on this, Nanning was selected as the research area. Based on urban community planning and modern epidemiological research, using the new coronavirus pneumonia data before April 15th, administrative division spatial data and land data, a “community physical examination model” (CPEM) was proposed on the base of PSR (stress-state-response) planning logic and analysis program. A 15-minute life circle as the examination unit, comprehensively derive the community health index (CHI) and the various epidemic prevention capabilities was calculated by CPEM by the rapid spread of the epidemic. Firstly, the environmental pressure source of the built-up area was analyzed, then the livability of the urban people was evaluated, and finally the community space environment was optimized. The public point system includes the analysis of the facility group pressure, the distribution of public point evaluation, and finally the optimization of urban space facilities suggestions. The epidemic system focuses on the pressure analysis of epidemic situation aggregation to evaluate the spread of epidemic disease, and ultimately assists in the optimization of the layout of the intercity space. Based on the PSR planning logic, the overall survival pros and cons of the urban community under the impact of the epidemic can be evaluated by these three parallel systems (urban people, public places and epidemics). It could provide targeted suggestions for the community defense response measures under the impact of this outbreak and the orderly improvement of the community space in the future. The results showed that: 1) The Community Physical Examination Model (CPEM) can effectively delineate the sub-health community unit in Nanning (CHI <5). CPEM has a powerful single-factor evaluation of the epidemic prevention level and comprehensive CHI calculation ability, which can comprehensively examine the health level of the community and find specific impact factors. However, the ability of community management calculation is weak because there are few policy indicators and human-based psychological indicators. 2) The 15-minute community life circle can work well as the minimum evaluation unit of CPEM. The 15-minute community life circle is different from the grassroots organizations such as streets and neighborhood committees that rely on national administration in the past. It can better play the self-organization of residents from the bottom up, thus establishing a self-management management and mutual assistance complementary mechanism for the basic unit of community medical examination. It is the core unit for building urban defense space and physical examination under public health emergencies in the central urban area of Nanning. 3) The community units with super high scores are arranged in the southeast corner of Nanning city center. The function types are residential communities and industrial communities. The uniform characteristics reflect the general paradigm of a healthy community: excellent ventilation, easily cut off pollution sources, a livable environment and convenient public services. In addition, sub-health community units with a score of less than 5 are distributed in the center of the city, mostly on the north bank of the Yongjiang River, with high construction density and poor ventilation environment. Old town facilities, unreasonable street directions, and sanitation prevention measures are the main causes of sub-health. Street micro-renewing of old communities and residents and hygiene awareness training will become the primary tasks of such units in future community construction. In all, the results showed that the sub-health units which are below 5 points were distributed in the center of the city, and all of them had a high construction density and poor ventilation environment. At the same time, it puts forward some targeted planning and management suggestions to provide references for the effective management of the community under the threat of urban public health