First, this paper addresses the conception of resilience by examining its genesis and evolution in history, followed by the exploration of its connotation from four major disciplinary perspectives of psychology, ecology, disaster risk reduction, and urban and regional studies. Drawing on the results of our exploration and other materials, it attempts to reconstruct the concept of resilience from a socio-spatial perspective. It defines urban socio-spatial resilience as the social and spatial stability and adaptability when urban socio-space suffering acute crises or chronic stresses endogenously or exogenously. It also promotes a three-phased structural model of urban socio-spatial resilience, which consists of anticipation as proactive action, adaptation as reactive action and anagenesis as learning action, aiming to provide a theoretical basis for thinking about the full range of potential response to the challenge of emerging complex social and spatial phenomena.