Transition of development zone is an important content of new urbanization in China. To improve the quality of the transition development, it should further clarify the transition path, pattern and relevant strategies. By reviewing the development of Suzhou development zone, this paper summarizes two kinds of patterns in development zone through case comparison. Basing the transition target on constructing comprehensive city, this paper points out a transition pattern about building three-phase interactive development model, including industry, human resident and ecology. Finally, the paper puts forward several specific optimization strategies during transition.